Dietary Supplements

MICROENCAPSULATED IRON

This microencapsulated iron ingredient allows the fortification of foods with iron without changing the appearance, palatability or taste. AB-Fortis^® remains stable in high pressures and temperatures, therefore staying intact during processing. In addition, the encapsulation protects oxidation-sensitive ingredients such as vitamins and fatty acids from oxidation. AB-Fortis^® is highly bioavailable as shown by a human clinical study on bioavailability¹

AB-Fortis^® is produced by a patented manufacturing process, which provides stable encapsulation that leads to a minimal release of free iron in the food matrix. The spherical gelation of ferric saccharate by calcium alginate results in a microencapsulated iron salt with a high (40%) content of iron.

• Microencapsulated iron salt
• High concentration (40% iron)
• High stability and no metallic taste
• Reduced gastrointestinal side effects²
• High bioavailability confirmed by human clinical study
• The addition of iron allows for the use of approved health claims in Europe

References:
¹ Contreras et al., European Journal of Nutrition 2013
²  Friling et al., International Journal for Molecular Sciences 2022

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NATURAL BLOOD PRESSURE SUPPORT

The leaves of the olive tree have traditionally been used since ancient times for various potential health benefits such as maintaining healthy blood pressure, cholesterol and blood sugar levels. Olive leaves have also been studied for their strong antimicrobial and antioxidant properties.

In a clinical trial with borderline hypertensive adult twins, Benolea^® intake confirmed the dose-dependent antihypertensive and cholesterol-lowering effects of Benolea^®1. The study also showed a significant reduction of LDL cholesterol. Benolea^® intake had positive effects on blood lipid profiles² and had a prophylactic effect on the development of high blood pressure and was associated with a beneficial effect on normal blood pressure^2-3.

• Olive leaf extract (Olea europaea L.)
• Support for cardiovascular health and wellness
• Uses and safety demonstrated by clinical research
• High oleuropein and polyphenol content
• High purity and stability thanks to EFLA®HyperPure process
• Organic version available

References
¹ Perrinjaquet-Moccetti et al., Phytotherapy Research 2008, 22
² Susalit et al., Phytomedicine 2011, 18
³ Khayyal et al., Arzneim.-Forsch./Drug Res. 2012, 11

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NATURAL BETAINE

A highly purified form of anhydrous betaine, BetaPower^® Natural Betaine is extracted from the molasses of sugar beet using a proprietary process.

BetaPower^® Natural Betaine helps fitness oriented consumers get a natural boost in their performance while aiding several important metabolic functions.

• Improves strength & power
• Increases physical endurance
• Promotes hydration
• Supports normal homocysteine metabolism
• Enhances flavor

Also known as trimethylglycine or TMG, betaine is found in many healthy foods, such as whole grains, spinach and beets. When consumed as part of a daily diet, betaine helps maintain cellular hydration and contributes to a healthy metabolism.

BetaPower^® offers a natural solution for improving strength, endurance and recovery. These benefits apply to a multitude of sports for athletes or any fitness enthusiast.

References:
¹ Hoffman, J.R., et al., J Int Soc Sports Nutr, 2009. 6(1): p. 7-17.
² Lee, E.L., et al., J Int Soc Sports Nutr, 2010. 7(1): p. 27.
³ Trepanowski, J.F., et al., J Strength Cond Res, 2011. 25(12): p. 3461-71.
⁴ Hoffman, J.R., et al., J Strength Cond Res, 2011. 25(8): p. 2235-2241.

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STIMULATES DETOXIFICATION

BroccoRaphanin^® is an innovative broccoli raffinate produced from a special variety of raw materials to achieve a naturally high level of glucoraphanin, a phytochemical shown to promote cellular health.

The proprietary production process focuses on the conservation of broccoli’s essential bioactive components. When glucoraphanin is consumed it is converted to sulforaphane, an isothiocyanate, which is an inducer of the body’s natural detoxification system enzymes. These enzymes eliminate many types of free radicals and environmental pollutants and trigger antioxidant action. The cellular mechanisms linked to the biological activity of BroccoRaphanin^® include a protective effect attributed to sulforaphane. The protective effects of vegetables from the Brassica family, such as broccoli, are well documented. Scientific research shows the mechanism of action is derived from the conversion of the precursor glucoraphanin to sulforaphane by myrosinase, an enzyme present in the gut microflora.

10% Minimum glucoraphanin content
Long-term stability and valuable nutritional profile
Supports detoxification mechanisms of the body
Supported by clinical data

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NATURAL IMMUNE, STRESS AND DIGESTIVE SUPPORT

Chamomile is one of the oldest, most widely used, and well-documented medicinal plants in the world. It has been used for centuries as an anti-inflammatory, antioxidant and mild astringent agent.

The main constituents of chamomile flowers are polyphenol compounds, including apigenin, which is known to have anti-inflammatory properties.

In Europe, according to the Committee on Herbal Medicinal Products (HMPC), preparations of Chamomilla recutita flowers are traditional herbal medicines used for the treatment of symptoms of different conditions, such as minor gastrointestinal complaints.

• Water and water-ethanolic extracts of Chamomile flower (Chamomilla recutita)
• Premium quality standardized on polyphenols such as apigenin
• Complete traceability from raw material to extract
• Strict control of contaminants such as PAHs
• Manufactured in NSF-GMP certified production site

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MEDITERRANEAN SYNERGY FOR HEART HEALTH

CitrOlive™ is the product of extensive research into the major phytochemicals, polyphenols and flavonoids that characterize citrus and olive and provide strong antioxidant activity. CitrOlive™ delivers phytonutrients common to the Mediterranean diet in concentrated form. The broad range of benefits include immune-related and antioxidant effects and cardiovascular endothelium protection¹.

• Patented blend of bitter orange and olive leaf extracts
• Supports cardiovascular health and wellness
• Supports beneficial vascular relaxing effects
• Uses and safety supported by clinical studies

References:
¹ López-Carreras et al., Food Research International 2015

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A BLEND OF OLIVE AND CITRUS DESIGNED FOR CARDIOVASCULAR SUPPORT

CitroVen™ is a blend developed after extensive research into the major phytochemicals, polyphenols and flavonoids of olive and specific citrus species.
CitroVen™ combines active components from three botanicals for their positive effects on blood pressure and vascular function. It delivers the protective phytonutrients of the Mediterranean diet in a tailor-made optimized blend for support of cardiovascular health.

A recent clinical study demonstrated the combination of citrus flavones and flavanones and olive polyphenols in CitroVen™ had a positive effect on the reduction of cardiovascular risk in healthy subjects.

References:
1. Sánchez Macarro, M. et al, Nutrients 2020

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NEXT GENERATION CURCUMIN

Curcugen™ is a highly concentrated, clinically studied curcumin ingredient, fully derived from a turmeric base with a high, 50% curcuminoid concentration.
It is derived from turmeric oleoresin as base ingredient with a more comprehensive profile of turmeric bioactives than the industry-standard starting material, 95% curcuminoids.

The oleoresin is the native matrix where turmeric’s curcuminoids, essential oils and resins are found, which support its unique characteristics.

The Curcugen™ oleoresin is optimized by the patent-pending SELFD™ platform technology. In this unique format, the natural ratio of curcuminoids is maintained, its beneficial essential oils are retained, and otherwise discarded resins are made functional. The functional resins in Curcugen™ add significant value to the ingredient, enhancing the bioavailability and dispersion properties.

A clinical study demonstrated this unique technology enhances free curcumin’s bioavailability 39 fold¹. Curcugen™ has a self-dispersion profile for easy and versatile delivery options, and provides a sustained release mechanism for efficient dosing.

• Fully natural turmeric- oleoresin extract
• Patent-pending SELFD™ technology
• 50% curcuminoids
• Retained turmeric essential oils
• Curcuminoid ratios similar to curcuma roots
• Sustained released mechanism
• Self-dispersing properties
• Versatile delivery options
• Clinically tested

Reference:
¹ Panda et al., Medicine (Baltimore), 2021,100

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DRY PRESSED JUICE FROM ECHINACEA PURPUREA

• Cold pressed juice from Echinacea purpurea
• Natural support for immune system function
• Efficacy and safety supported by preclinical, clinical, and stability data
• Complies with the European Pharmacopeia Monograph
• Gluten-free, non-allergenic, non-GMO
• Available for use in a wide range of applications

Echinacea is initially described as a traditional medicine of the Native Americans of the Great Plains region. It was used as a remedy for more ailments than any other plant, including use for fever, sore throat, wound healing and skin health. Echinacea has been promoted for years as a dietary supplement to help support a healthy immune system in adults, particularly in the elderly.

Echinacea EFLA^®894 is a unique cold pressed juice from freshly harvested aerial parts of the Echinacea purpurea plant.

• Supports immune system function
• May enhance immune system function during stressful conditions

References:
1. Park et al., Journal of Medicinal Food 2018
2. Fujii et al., Pharmacometrics 2011
3. Isbaniah et al., Journal of Clinical Pharmacy and Therapeutics 2011
4. Antiviral effects of Echinacea EFLA ^® 894 and Pelargonium EFLA ^® 956, 2011, Data on file at IFF
5. Burger et al., International Journal of Immunopharmacology 1997

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HARNESS THE BENEFITS OF A UNIQUE SOLUBLE FIBER

FenuLife^® is a unique source of galactomannan fiber produced from Trigonella foenum-graecum, a non-GMO proprietary variety of fenugreek. A clinical study demonstrated FenuLife^® supports digestive health in individuals who experience infrequent stomach acid reflux. FenuLife^® had positive beneficial effects on heartburn symptoms as compared to a placebo, and had similar effects to a positive control. Previous clinical studies support the use of FenuLife^® for healthy weight management. FenuLife^®’s benefits are likely a result of increased satiety and positive effects on the glycemic index.

• Highly concentrated fenugreek galactomannan, standardized on 85% total fiber
• Patented natural and safe solution to support digestive health
• Highly resistant to enzymatic degradation
• Sustainable water binding capability throughout the digestive tract
• Low in calories

References:
1. Effect on blood glucose in type-II diabetes 2002, data on file at IFF
2. Effect on glycemic responses 2002, data on file at IFF
3. Mathern et al., Phytotherapy Research, 2009
4. DiSilvestro et al., Phytotherapy Research, 2010

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PURE, NATURAL COGNITIVE SUPPORT

Ginkgo biloba is an ancient plant that is often used in traditional Chinese medicine. Ginkgo trees can live as long as a thousand years. Traditionally, Ginkgo biloba extract is used to stimulate circulation and oxygen flow to the brain, thereby supporting the improvement of cognitive function and memory.

• Ginkgo biloba extract
• Well-known and well researched botanical ingredient to support cognitive function
• Peace of mind through ethical sourcing and routine contaminant and authenticity testing
• 100% natural, unadulterated product, no additives

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HIGHLY AUTHENTICATED AND PURIFIED GINSENG

Panax ginseng has been used for several thousand years in Asia as a tonic, believing it is a panacea and that it promotes health, vitality, and longevity. The earliest records of ginseng’s use in medicine can be found in the Chinese Materia Medica, approximately 2000 years ago.

In Europe, according to HMPC preparations of Panax Ginseng C.A. Meyer, root extracts are a traditional herbal medicine to manage symptoms of asthenia or abnormal fatigue and physical weakness.

• Ginseng root extract (Panax ginseng C.A. Meyer)
• Strict raw material selection (more traditional profile from 4-7 year old whole roots)
• Exclusive EFLA^® HyperPure manufacturing process guarantees purity, solubility, and stability

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BLADDER WELLNESS SUPPORT IN MEN AND WOMEN

Human clinical studies demonstrate Go-Less^® supports urinary bladder function and addresses urinary urgency in both men and women. As shown in a randomized placebo controlled trial and three open label studies, Go-Less^® statistically significantly reduced:

• Urination frequency
• Nocturia frequency
• Frequency of urgency

Participants demonstrated a high degree of satisfaction in all studies.

• A clinically researched natural solution for bladder wellness
• Efficacy and safety supported by published clinical studies
• Positive effects demonstrated in both men and women
• Consumer satisfaction proven
• Pumkin seed extract made with proprietary EFLA^®HyperPure production process
• Soy germ extract high in isoflavones

References:
1. Shim et al., Journal of Functional Foods 2014, 8
2. Terado et al., J. of Medicine and Pharmaceutical Science 2004, 52
3. Yanagisawa et al., J. of Medicine and Pharmaceutical Science 2003, 14
4. Sogabe and Terado, J. of Medicine and Pharmaceutical Science 2001, 46

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PUMPKIN EXTRACT FOR MALE URINARY HEALTH

Go-Less^® Men, IFF Health’s pumpkin seed extract EFLA^®940, helps support healthy male urinary function. An open label clinical study of Go-Less^® Men showed an improvement in many aspects of bladder health and urination reported in patients with benign prostate hyperplasia (BPH) and contributed to an improved quality of life¹.

• Efficacy and safety of pumpkin seed extract supported by published clinical studies
• Complies with the monograph of the European Herbal Medicine
• Promotes healthy bladder function, as shown in men with benign prostatic hyperplasia (BPH)
• Non-GMO Project Verified

Studies using Go-Less^® Men (EFLA^®940) support bladder health benefits¹:

• Nocturia significantly decreased over time
• Postvoid residual urine volume was significantly reduced
• The positive impact on bladder health had a high impact on quality of life

Reference:
¹ Leibbrand et al., Journal of Medicinal Food, 201

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NATURAL APPETITE AND METABOLISM SUPPORT

The leaves of the South American evergreen mate tree (Ilex paraguariensis St. Hil.) have traditionally been used as a natural medicine for many purposes, ranging from appetite control to physical and mental stimulation. The herb is an important component of many popular drinks, most commonly referred to as Paraguay Tea. Traditionally, the drink is held in a gourd and sipped with a metal straw and sharing the drink can be a sign of friendship and bonding. In recent years we have seen a resurgence of this ingredient across a multitude of functional beverages, notably teas and energy drinks.

• Green Mate extract (Ilex paraguariensis St. Hil.)
• Natural appetite and metabolism support
• Increases physical and mental performance
• Unique standardization on 5 key components

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HYPERPURE GREEN TEA

According to Asian tradition, green tea is able to provide relief for anything from headaches, body aches, and pains to constipation and depression. Green tea is a traditional daily refreshment in Japanese and Chinese cultures and is becoming increasingly popular in European and North American cultures.

• Extraction from young leaves of Camellia sinensis
• Multicomponent system: develops its activity profile by the synergic effect of its components
• Produced using EFLA^® HyperPure patented technology: purity, solubility, and stability

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ENHANCED NUTRIENT ABSORPTION AND BIOAVAILABILITY

Grow Nutrients^® are vitamins, minerals, or amino acids in an enriched single-cell system that mimics nature. “Grown” in single-cell systems such as bakers’ yeast (Saccharomyces cerevisiae) or a probiotic strain (Lactobacillus bulgaricus), Grow Nutrients^® are better recognized and better absorbed by the human body^2-3. The body recognizes Grow Nutrients^® as a food complex, rather than as an isolated mineral, resulting in superior absorption and assimilation to promote cell growth and repair.

Grow Nutrients^® use a proprietary manufacturing process based on a yeast or a probiotic strain culture that converts isolated nutrients into a whole food complex that is readily absorbed and bio-available, providing nutrients as a whole food. Grow Nutrients^® is backed by 20 years of research.

Our studies show significantly increased bioavailability of Grow Nutrients^® compared to the isolated minerals.

References:
¹ Vinson and Bose, 1988. American Journal of Clinical Nutrition 48(3):601-4
² Vinson and Bose, 1987. Selenium in Biology and Medicine Part A, New York, 1984:445-9
³ Vinson, unpublished, Comparison of the Bioavailability of Combination Vitamin and Mineral Supplements
⁴ Vinson and Bose, Proceedings on Mineral Elements, 615-621, 1981.

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NATURAL CAFFEINE

Guarana (Paullinia cupana) is a species of climbing plant native to the Amazon that is known as an antioxidant, traditional medicinal, with natural stimulant effects. The Guarana name comes from the Guarani tribe that lives in Brazil. The herb plays a very important role in their culture as it is believed to be magical; a cure for constipation, and a way to regain strength.

• Commonly used in energy, sports nutrition products
• Contributes to weight and appetite management
• Guarana extract (Paullinia cupana)
• Strict raw material selection
• Strict control of pesticides and polycyclic aromatic hydrocarbons (PAHs)

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HELPS TO MANAGE THE PSYCHOLOGICAL RESPONSE TO STRESS

Lacticaseibacillus paracasei Lpc-37^®, previously known as Lactobacillus paracasei Lpc-37^®, has been studied alone or in combination with other strains. It is frequently studied alongside of NCFM^®, Bi-07^®, and Bl-04^® as part of the HOWARU^® Restore blend for digestive health¹. Lpc-37^® has also been studied for its impact on managing the psychological response to stress². Lpc-37^® has been cited in more than 65 scientific publications, including more than 21 clinical trials. It has a long history of safe use, is well suited for intestinal survival, and has strong adhesion to intestinal cell lines and pathogen inhibition^3-4.

References:
¹ Ouwehand et al., Vaccine. 2014;32:458-463.
² Patterson et al., Neurobiol Stress. 2020;13:100277.
³ Ding et al., J Food Sci. 2007;72:M446-450.
⁴ Gibson et al.,. Br J Nutr. 2005;93(Suppl. 1):S31-34.

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BIFIDOBACTERIUM ANIMALIS SSP. LACTIS Bi-07^®

B. lactis Bi-07^® has been studied alone and frequently alongside NCFM^®, Bl-04^®, and Lpc-37^® as part of the HOWARU^® Restore blend for digestive health¹. It has also been clinically studied in combination with NCFM^® for early life health². Extensive in vitro and in vivo studies support the health-enhancing, probiotic properties of B. lactis Bi-07^®. The strain has been published in more than 91 scientific publications and in 33 clinical trials that extend from toddlers (7 months of age) to aging populations (70 years of age). Bi-07^® has a long history of safe use, is well suited for intestinal survival, and has strong adhesion to intestinal cell lines^3-9.

References:
¹ Ouwehand et al., Vaccine. 2014;32:458-463.
² Leyer et al., Pediatrics. 2009;124(2):e172-179.
³ Candela et al., J Bacteriol. 2007;189:5929-5936.
⁴ Candela et al., Microbiology. 2009;155:3294-3303.
⁵ Candelaet al., Microbiology. 2008;154:2457-2462.
⁶ Candela M, Perna F, Carnevali P, et al. Interaction Int J Food Microbiol. 2008;125:286-292.
⁷ Candela et al., J Microbiol Methods. 2008;73:276–278.
⁸ Candela et al., Res Microbiol. 2005;156:887–895.
⁹ Candela et al., Appl Environ Microbiol. 2011;77:7072-7076.

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HELPS MAINTAIN A HEALTHY RESPIRATORY FUNCTION

B. lactis Bl-04^® is a human isolate long considered safe and suitable for human consumption. Known for its excellent stability, Bl-04^® has been present in a variety of foods and supplements for decades. It has also been shown to survive passage through the human intestine^1-2. Bl-04^® studies suggest it mechanistically modulates the immune system, and clinical data supports the use of this strain for Immune Health^3-4. With more than 24 clinical trials, Bl-04^® has also been studied in combination with other strains, including NCFM^®, Bi-07^®, and Lpc-37^® as part of the HOWARU^® Restore blend for Digestive Health⁵.

References:
¹ Bartosch et al., Clin Infect Dis. 2005;40:28-37.
² Ouwehand et al., World J Gastroenterology. 2009;15.
³ Turner et al., Beneficial Microbes. 2017;8:207-215.
⁴ West et al., Clin Nutr. 2014;33:581-587.
⁵ Ouwehand et al., Vaccine. 2014;32:458-463.

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HELPS TO MAINTAIN A HEALTHY, ACTIVE IMMUNE SYSTEM IN AGING ADULTS

B. lactis HN019™ has been consumed in dairy foods for decades and is well-studied for its probiotic properties in more than 111 scientific publications. It has been demonstrated to tolerate acidic conditions and shown to survive passage through the human intestine^1-3. Mechanistic data suggests HN019™ may influence colonic motility, and multiple clinical trials with HN019™ alone or in combination with prebiotics or other probiotic strains have resulted in increased gut transit in persons with less frequent bowel movements^4-6. HN019™ has also been shown to modulate immune function, particularly enhancing cellular immune activity in aging persons⁷.

References:
¹ Gopal et al., Nutrition Research. 2003;23:1313-1328.
² Prasad et al., Intl Dairy J. 2013;30:64-67.
³ Wickens et al., J Allergy Clinical Immunology. 2008;122:788-794.
⁴ Dalziel et al., Frontiers in Neuroscience. 2017; 11.
⁵ Ibarra Gut Microbes. 2017; Dec 11:0.
⁶ Waller et al.,Scandinavian J Gastroenterology. 2011;46:1057-1064.
⁷ Miller et al., Nutrients. 2017;9:191.

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SUPPORTS DIGESTIVE HEALTH AND GUT COMFORT

L. acidophilus NCFM^® was first isolated from a human source in the early 1970s. NCFM^® has been safely investigated in more than 330 scientific studies, including more than 60 human clinical trials as a single entity and in combination with other probiotics and prebiotics. It has been studied alongside other strains as a component of the HOWARU^® Restore Blend (NCFM^®, Lpc-37^®, Bi-07^®, Bl-04^®) for digestive health and with Bi-07^® for early life health^1-2. The subjects in these trials have ranged from infants to aging populations (from 6 months to over 65 years of age). It has a long history of safe use, is well suited for intestinal survival, and has strong adhesion to intestinal cell lines^3-4.

References:
¹ Ouwehand et al., Vaccine. 2014;32:458-463.
² Leyer et a., Pediatrics. 2009;124(2):e172-179.
³ Andreasen et al., Br J Nutr. 2010;104:1831-1838.
⁴ Kleeman et al., J Dairy Sci. 1982;65:2063-2069.

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LACTOBACILLUS ACIDOPHILUS La-14^®

Lactobacillus acidophilus La-14^® is a lactic acid bacterium of human origin that has been documented in over 50 scientific studies, including 18 clinical trials. Preclinical studies have shown La-14^® can impact both the innate and adaptive immune system^1-2. These effects and antipathogenic activity are thought to be potential mechanisms behind the efficacy of La-14^® combined with HN001™ in women’s health^3-4. In addition, these two strains together have been shown to support healthy vaginal colonization through oral supplementation⁵.

References:
¹ Elawadli et al., Beneficial Microbes. 2014;5(3):323-334.
² Paineau et al., FEMS Immunol Med Microbiol. 2008;53(1):107-113.
³ Bertuccini et al., Intl J Immunopathology Pharmacology. 2017;30(2):163-167.
⁴ Jang et al., Nutrients. 2017;9:531; doi:10.3390/nu9060531.
⁵ De Alberti et al., Arch Gynecol Obstet. 2015;292(4):861-867.

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SUPPORTS WEIGHT MANAGEMENT AND HELPS KEEP YOUR WAIST TRIM

B. lactis B420™ has been documented in more than 60 scientific studies, including 16 clinical trials. It has been demonstrated in clinical trials to survive intestinal passage, and in vitro studies have shown excellent adhesion to human colonic mucus^1-3. The primary health attributes of B420™ are weight management and metabolic health, which may be related to its ability to support intestinal barrier integrity^4-6. In addition, Akkermansia muciniphila, a bacterial species linked to lean healthy body weight, was increased in abundance in the intestine upon B420™ supplementation⁷. B420™ has demonstrated promise in both human clinical trials and animal studies in supporting weight management and inducing a better metabolic state^8-10.

References:
¹ Klein et al., Eur J Clin Nutr. 2008;62:584-659.
² Kok et al., Appl Environ Microbiol. 1996;62:3668-3672.
³ Collado et al., Lett Appl Microbiol. 2007;45: 454-460.
⁴ Lindfors et al., Clin Exp Immunol. 2008;152:552-558.
⁵ Putaala et al., Res Microbiol. 2008;159;692-698.
⁶ Mokkala et al., Nutr Res. 2016;36:246-252.
⁷ Hibberd et al., Beneficial Microbes. 2018;1-16.
⁸ Stenman et al, BioMedicine. 2016. Nov;13:190–200.
⁹ Stenman et al., Diabetology & Metabolic Syndrome. 2015;7:75.
¹⁰ Stenman et al., Beneficial Microbes. 2014;5:437-445.

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SUPPORTS IMMUNE HEALTH OF EXPECTANT MOTHERS AND INFANTS

Lacticaseibacillus rhamnosus HN001™ has been consumed for more than 20 years in foods and supplements and documented in more than 100 scientific publications. It was originally selected as a probiotic candidate due to its high tolerance to acidic conditions, and was subsequently shown to survive passage through the human intestine^1-3. HN001™ has been extensively studied across all life stages from early infancy through elderly years, and in pregnant and lactating women. Most notable is its ability to impact the immune system and long-term safety profile in infants and children to support early life immune homeostasis^3-6. Also, when combined with La-14^®, HN001™ supports healthy bacterial colonization for women’s health⁷.

References:
¹ Prasad et al., Int Dairy J. 1998;8:993-1002.
² Tannock et al., Appl Environ Microbiol. 2000;66:2578-2588.
³ Wickens et al., J Allergy Clin Immunol. 2008;122(4):788-794.
⁴ Wickens et al., Clin Exp Allergy. 2012;42(7):1071-1079.
⁵ Wickens et al., Clin Exp Allergy. 2013;43(9):1048-1057.
⁶ Wickens et al., Pediatr Allergy Immunol. 2018;29(8):808-814.
⁷ De Alberti et al., Arch Gynecol Obstet. 2015;292(4):861-867.

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SUPPORTS IMMUNE HEALTH OF MOTHER AND BABY

HOWARU^® Protect Prenatal+ supports the health of mother and child during pregnancy and beyond. This clinically-studied product not only promotes vaginal health but also happiness and calmness in new mothers. In addition, this combination of strains has also been shown to support healthy immune function in both mothers and their infants.

• Supports the immune health of expectant mothers and their infants
• Helps promote healthy blood glucose levels in pregnant women
• Supports positive postpartum mood
• Helps maintain a healthy vaginal microbiota and pH Contact us for further information.

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PROMOTES HEALTHY VAGINAL MICROBIOTA FOR OVERALL VAGINAL HEALTH

HOWARU^® Feminine Health features clinically-documented probiotic strains for vaginal health and overall feminine wellness. This formulation has been shown to promote healthy vaginal microbiota in addition to having beneficial effects regarding bacterial vaginosis and vulvovaginal candidiasis when administered in conjunction with metronidazole or clotrimazole treatment, respectively.

• Formulated exclusively for women’s vaginal health and wellness
• Helps maintain healthy vaginal microbiota and pH.
• Results seen in 7 days

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PROMOTES DIGESTIVE BALANCE AND RESILIENCE WITHIN THE DIGESTIVE TRACT IN TIMES OF GI STRESS

HOWARU^® Restore is a documented probiotic blend shown to help replenish beneficial bacteria lost during times of dysbiosis. Its unique benefits are attributed to its formulation, which is comprised of equal amounts by number of bacteria adapted to upper intestine support as well as lower intestine support. This clinically proven formulation has been shown to not only quickly promote digestive regularity but also restore overall digestive comfort.

• Supports gut health
• Addresses duration of diarrhea
• Lessens days of gut disruption

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PROMOTES RESPIRATORY HEALTH IN CHILDREN

HOWARU^® Protect Kids is an effective probiotic formulation for immune support in children. It features a multi-strain combination which has been proven clinically to help children have fewer respiratory symptoms and fewer missed days of school than their peer group.

• Helps promote optimal health and wellness in children
• For maintenance of respiratory health in children
• Helps shorten duration of symptoms and supports fewer missed school days

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HELPS PHYSICALLY ACTIVE ADULTS STAY HEALTHY FOR OPTIMAL SPORTS PERFORMANCE

HOWARU^® Protect Sport is a premium probiotic solution developed specifically for sports enthusiasts. It has been clinically shown to support respiratory health and energy levels in physically active adults and to help athletes stay healthy.

• Helps physically active adults stay healthy for optimal sports performance
• Contributes to a significant increase in weekly exercise
• Supports immune health Contact us for further information.

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PROMOTES OVERAL GUT COMFORT AND SUPPORTS HEALTHY IMMUNE RESPONSE

HOWARU^® Balance is specifically designed to support digestive and immune health in adults ages 18-55. This unique formulation has been extensively studied in vitro and in animal models for characteristics considered to be important to digestive health. In addition, B. lactis HN019™ has been clinically proven in multiple human trials to demonstrate significant improvement in markers of immune health, suggesting that it contributes to strengthening the body’s natural defenses.

5B CFU | Lactobacillus acidophilus NCFM^® + 5B CFU | Bifidobacterium lactis HN019™

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SN2 PALMITATE (OPO) FAT INGREDIENT WITH 7 CLINICALLY TESTED BENEFITS

INFAT^® is a fat ingredient structured with a high level of palmitic in the middle position, similar to the structure of human milk fat. Human milk provides the optimal nutrition for infants.
It offers perfectly balanced nutrition, naturally meeting the needs of growing infants in the first months of life. At Advanced Lipids, we are inspired by human milk research, continuously studying its nutritional value.

INFAT^® has been clinically tested to bring multiple benefits to babies.

• More sleep
• Less crying
• Softer stools
• Healthy gut bacteria
• Fat absorption
• Bone strength
• Calcium intake

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IMPROVE THE HEALTH OF HAIR, SKIN AND NAILS
 
Keratin is a protein found in the body of humans and animals that makes up the structure of the fingernails, hair, and skin. Usually, natural keratin from animal sources is insoluble and indigestible. KeraAGEN-IV™, however, is a pure keratin protein that is gently extracted to make it fully bioactive and digestible.
KeraGEN-IV™ supports the body’s ability to make collagen IV and collagen VII. 
Collagen IV and VII are only made in the human body and can’t be replaced by dietary collagen. These unique collagens are responsible for skin strength and elasticity.

• Pure keratin protein
• Gently extracted to make it fully bioactive and digestible
• Made from sheep’s wool keratin, a renewable source with 91% human homology
• Sustainable harvesting and production
• Full ingredient traceability
• Non-GMO
• Formulation flexibility to allow inclusion in more product combinations and formats
• Currently not available in the US

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HIGH QUALITY AND BIOAVAILABLE LIGNAN PHYTONUTRIENTS

• Natural source of flax lignans (SDG) produced from selected flaxseed hulls
• Established bioavailability
• Supports healthy urinary/bladder function in men

LinumLife® is carefully produced from selected flaxseed hulls. Flaxseed has been recognized as the richest natural source of lignans, with a concentration more than 100 times higher than any other plant source in the human diet. LinumLife® is standardized on 20% lignans as secoisolariciresinol diglucoside (SDG). Lignans are complex classes of bioactive polyphenolic phytochemicals. They possess numerous biological properties that are useful in promoting various aspects of health including:

• Men’s health
• Prostate health
• Hair growth
• Maintenance of healthy hormone levels (SHBG, 5 α-reductase, DHT)

Many studies have evaluated the effects of LinumLife^®1-4.

References
¹ Bisson et al., Journal of Functional Foods 2014
² Simons et al., Journal of Medicinal Food 2014
³ Bioavailability of lignans in BPH patients, 2004, data on file at IFF
⁴ Reduction of hair loss in men with androgenetic alopecia, 2004, data on file at IFF

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LOW CALORIE PREBIOTIC POLYDEXTROSE

Litesse^® is a low calorie, low glycemic, specialty carbohydrate with prebiotic properties, that is widely recognized as a fiber around the world.

Litesse^® polydextrose boasts over 30 years of clinical studies in peer reviewed publications. Food and beverage products containing Litesse^® can offer consumers multiple benefits in the areas of digestive health, weight management and oral health. Litesse^® also facilitates the production of reduced sugar /calorie and fiber enriched, healthier alternatives which retain the taste, texture and eating quality of the original products.

• Dietary fiber
• Prebiotic properties
• Provides just 1 kcal/g
• Low glycemic ingredient
• Outstanding Toleration
• Superior functionality for sugar reduction

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NATURAL SUPPORT FOR BRAIN FUNCTION

Green oat preparations have been used since medieval times to address fatigue, poor concentration, and irritable mood. Green oats are harvested during the late stage of growth when the seed heads are still green and hard. Using a bioassay-guided development approach, IFF Health has scientifically substantiated and linked these effects to a selected green oat variety^1-4.

Neuravena^® intake has been associated with changes in brain activity based on effects in the left frontal temporal lobe area of the brain^1-2, an area known to be involved in cognitive tasks such as problem-solving, and memory. The effects of Neuravena^® intake were assessed using standardized psychological measures. Statistically significant effects were linked to Neuravena^® intake using a battery of tests selected to allow assessments across the major cognitive domains^3-4, i.e. concentration and alertness (Stroop color-word test), executive function (Peg and Ball), and episodic memory (COMPASS).

• Extract of a proprietary variety of oat herb selected for its superior biological activity profile
• Supports mental fitness/brain function
• Uses and safety supported by clinical studies
• High purity and stability thanks to EFLA^®HyperPure process

References:
¹ Dimpfel et al., Journal of Alternative Complementary Medicine 2011, 17
² Wong et al., Journal of Hypertension 2013, 31
³ Berry et al., Journal of Alternative Complementary Medicine 2011, 17
⁴ Kennedy et al., Nutritional Neuroscience, 2015

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LIQUID, SOLUBLE BOSWELLIA

Boswellia has been clinically studied. Boswellia serrata extracts derived from the gum of Indian Frankincense are used in traditional medicine. Boswellic acids are the main constituents responsible for the desired effects of boswellia in joint, gastrointestinal, and respiratory health and wellness.

NovaSOL^® technology provides a liquid micelle solubilized boswellia extract with unique properties that results in increased bioavailability.

Standard boswellia extracts usually have very limited bioavailability due to their poor water solubility. Improving the bioavailability of these compounds is key to assuring full bioactivity of boswellia.

A recently published scientific study demonstrated the enhanced absorption of boswellic acids from NovaSOL^® Boswellia in comparison with a native extract¹. The study demonstrated that this stable, highly bioavailable solubilisate resulted in higher levels of the active ingredients in the blood.

• Unique liquid micelle solubilized boswellia extract
• Increased bioavailability
• Promotes joint and digestive health, and respiratory health and wellness

References
1. Meins et al., NFS Journal 2018, 11

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LIQUID, SOLUBLE CURCUMIN

The dried, powdered root of the turmeric plant has a long history of use as an Ayurvedic, a natural system of medicine, for the support of various inflammatory conditions. While the biological effects of curcumin and its mechanism of action have been well documented in the scientific literature, its limited bioavailability is a major issue with respect to its use in an oral dose form. Because of low absorption and rapid metabolism, very high intake levels of a standard extract are needed to be biologically effective. A unique technology (liquid curcumin solubilisate) makes these compounds highly soluble therefore solving this problem and drastically increasing bioavailability.

The NovaSOL® solubilisation technology gives curcumin unique properties in a liquid format that result in rapid absorption and high bioavailability. This stable, highly bioavailable solubilisate means the ingredient can be used at much lower doses in an orally ingested product without diminishing efficacy or affecting safety.

• Unique liquid micelle solubilized curcuma extract
• Supported by clinical studies
• Increased bioavailability of curcumin (185x more)¹

References
¹ Schiborr et al., Molecular Nutrition & Food Research 2014, 58

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SUPPORTS HEALTHY BLOOD GLUCOSE LEVELS

Rich in valuable nutrients, the fleshy leaves of the purslane herb are appreciated as a culinary ingredient worldwide.
Purslane also has a long tradition of medicinal use. In Near Eastern folk remedies, the plant is treasured for its properties to positively affect blood glucose metabolism.
Purslane has been used as a remedy for a variety of ailments such as headaches and stomach pain or urinary discomfort in different parts of the world.

Portusana^® helps to regulate glucose metabolism through three mechanisms: reduction of intestinal glucose absorption, increased insulin sensitivity, and increased glucose uptake. Furthermore, stable and healthy blood glucose levels help to manage appetite by inducing satiety.

• Purslane herb extract (Portulaca oleracea L.) for natural blood glucose and appetite support
• Multiple identified modes of action to support healthy blood glucose metabolism. Uses and safety confirmed by clinical studies.

References
1. Stadlbauer et al., PLoS ONE 11, 2016
2. Wainstein et al., Journal of Medicinal Food, 2016

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A NATURAL NUTRIENT FOR BODY AND MIND

Phosphatidylserine (PS) is a natural building block of our tissues, found in every cell membrane. PS has been shown to play a crucial role in the structure and function of the brain, as well as in muscles and other tissues. Thus PS is an important building block of our bodies.

PS is a highly researched ingredient whose benefits support both body and mind. PS derived from soy has been clinically tested to improve cognitive performance¹, attention, and behavior² in addition to helping minimize feelings of stress for those who excite easily³ and supporting overall skin health⁴.

Backed by more than 50 clinical studies as well as significant amount of pre-clinical evidence demonstrating the safety and uses of PS intake as well as likely mechanism of action.

• Exclusive and patented grades
• Produced from a variety of sources
• Excellent organoleptic properties for use in functional foods
• Halal and Kosher certification

References:
¹ Tang et al., Chongqing Medicine., 2011
² Hirayama et al, J Hum Nutr Diet., 2014
³ Benton et al, Nutr. Neurosci., 2001
⁴ Choi et al„ J Korean Soc Appl Biol Chem., 2013

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SCIENTIFICALLY STUDIED SOY GERM ISOFLAVONES

SoyLife is a unique isoflavone ingredient manufactured exclusively from soy germ. In contrast to a whole soybean extract, a germ extract is rich in the isoflavone daidzein, considered one of the most active constituents in soy, which can be metabolized to equol.

Soy isoflavones are a class of phytoestrogens, which are clinically studied to support healthy endocrine function and hormone levels, manage menopausal symptoms and support post-menopausal, bone, metabolic and skin health. SoyLife is one of the most researched sources of soy germ isoflavones available with over 35 scientific studies to support it use and safety.

• Soy germ ingredient rich in daidzein and other phytonutrients
• Supports women’s health and well-being
• GMO-free and no harsh solvents are used
• Pure soy germ without carrier or preservatives
• High stability during processing
• Efficacy and safety confirmed by scientific studies

References
1. Chen et al., Menopause, 2004
2. Nahas et al., Maturitas, 2004
3. Wong et al., Am. J. Clin. Nutr. 2009
4. Ye et al., Menopause, 2012

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NATURAL VITAMIN K2

Vitamin K2 plays an essential role in the activation of several vitamin K-dependent proteins involved in our calcium metabolism and can be considered as the missing link for improved bone and cardiovascular health. As the typical Western diet contains insufficient amounts of this essential vitamin, daily intake of additional vitamin K2, specifically menaquinone-7 (MK-7), will support optimal calcium metabolism, including the ideal use of calcium in the bone building process and promote the prevention of calcification of blood vessels and kidneys. MK-7 is the most bioavailable and bioactive form of vitamin K2 and its activity is well described and supported by many clinical studies.
UniK2^® contains traditionally fermented, fully natural vitamin K2 MK-7, with high purity and stability, for use in food supplements and fortified foods.

• Vitamin K2 is produced by the fermentation of soy by Bacillus subtilis. Authorized EU Novel Food.
• Natural vitamin K2 as menaquinone-7 (MK-7) derived from natto
• Most bioavailable and most bioactive form of vitamin K
• High purity and stability
• Supports bone and cardiovascular health

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