Excipients for Pharmaceuticals

The superior disintegrant

Ac-Di-Sol® Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules.

• Superior Performance: Provides excellent water uptake and rapid swelling properties, resulting in a faster disintegration and dissolution than competitors, and at lower use levels (1-2%).
• Broad Functionality: Utilized in a variety of processes, including direct compression, dry and wet granulation, and continuous manufacture processes. It works across dosage forms - from tablets to capsules to granules and more.
• Purity: Exhibits consistent critical material attributes such as fibrous morphology, low moisture content, low impurities and low water-soluble content, resulting in robust and reliable performance.

Contact us for further information.

Solving the Insoluble

AFFINISOL™ hydroxypropyl methylcellulose (HPMC) is a water-soluble cellulosic polymer that can help optimize solubility enhancement of poorly soluble drugs by maintaining stable solid dispersions and inhibiting API crystallization.

More sophisticated drug discovery techniques have led to pipeline compounds that require solubility enhancement to be therapeutically effective. Solid dispersions are one of the key technologies for formulating oral solid dosage forms containing APIs with bioavailability challenges. AFFINISOL™ HPMC has been specifically designed for generating solid dispersions via spray-drying (SDD) or hot melt extrusion (HME) in the pharmaceutical industry.

AFFINISOL™ HPMC HME offers hot melt extrusion process flexibility in choosing a polymer viscosity that optimizes drug release profiles and against the factors affecting solubility. The polymer’s added organosolubility further creates advantages for employing HPMC in solvent spray-drying applications.

Contact us for further information.

Unique functionality for a broad range of pharmaceutical applications

Alginate drug delivery harnesses the unique properties of seaweed for premier performance in multiple pharmaceutical and nutraceutical applications; they impart viscosity in solutions and even form a three-dimensional gel in the presence of calcium ions. This unique functionality can be used in a diversity of applications such as controlled release dosage forms, enteric coatings, microencapsulation and stabilization in solutions and suspensions.

Alginates also function as actives in some anti-reflux products. Alginates from IFF are an excellent choice for consistent performance in a variety of applications. From anti-reflux to biomedical implants, alginates are uniquely suited for a wide range of applications. IFF has decades of experience controlling these naturally derived materials, which means you can count on consistent performance, every time.

Contact us for further information.

High performance lubricant that brings more to the tablet

Alubra® sodium stearyl fumarate from IFF Pharma Solutions is a comparatively hydrophilic lubricant widely used in capsule and tablet formulations. The fumarate moiety of Alubra® increases its melting temperature, which allows for greater functionality at high press speeds while the stearate chain maintains the lubricity of the compound and supports low ejection forces. Alubra® is also less susceptible to over-blending contributing to more flexible process conditions and reduced waste due to over blended batch failures.

Contact us for further information.

The aqueous solution to barrier membrane coating

Aquacoat® sustained release coating is a pseudo latex aqueous dispersion of water insoluble polymers used for sustained and enteric coating applications.

Aquacoat® ECD is an aqueous dispersion of ethylcellulose used for sustained release barrier or slow release pharmaceutical coating, moisture barrier and taste masking applications for tablet and multi-particulate dosage forms. Aquacoat® CPD is an aqueous dispersion of cellulose acetate phthalate used for enteric release applications. This grade of polymer film remains intact at pH< 6, thus protecting the API in gastric environments.

Contact us for further information.

Synergies to simplify formulation challenges and reduce operational costs 

Avicel® co-processed grades are co-spray dried blends of Avicel® microcrystalline cellulose with synergistic pharmaceutical excipients to yield functional benefits beyond simple physical blends. 

Synergistic solutions

Co-processed excipients deliver functional synergies to address formulation challenges with simplified, single ingredient solutions. Avicel® co-processed products are high functionality excipients offering improved powder flow, granule properties, tablet compression, and mouth feel. 

These co-processed products are designed to solve complex formulation problems, simplify manufacturing processes, and deliver significant cost savings. 

Contact us for further information.  

An excellent choice for modified release

ETHOCEL™ premium ethylcellulose resins are water-insoluble polymers. They are soluble in a wide range of organic solvents, beginning with aliphatic alcohols such as ethanol and isopropanol, and are compatible with most other familiar organic solvent chemistries, including ether alcohols, ketones, aromatic hydrocarbons and many more.

Contact us for further information.

A family of polysaccharide products that allow distinctive drug delivery solutions

Carrageenan is a naturally occurring family of hydrophilic polysaccharides extracted from several closely related species of red seaweeds. They are high molecular weight, highly sulfated, linear molecules with a galactose backbone. They are made up of sulfated and non-sulfated repeating units of galactose and 3,6-anhydrogalactose.

The range of products includes three basic types of carrageenan – kappa, iota and lambda from various species of red seaweed. They are differentiated from each other by the amount of 3,6-anhydrogalactose as well as the number and position of ester sulfate groups present.

Natural rate modifying polymers

Various Gelcarin® and Viscarin® carrageenan grades are used by the pharmaceutical industry to achieve specific gelling for controlled drug release, thickening, and stabilizing properties desired in various formulations.

Contact us for further information.

Delivering efficient and robust formulations

GRINDSTED® Xanthan Gum is a naturally fermented product of carbohydrates and is applied in various liquid, semi-solid and solid pharmaceutical dosage forms.

GRINDSTED® Xanthan Gum readily dissolves in water under ambient conditions without the need of special high-shear equipment. As one of the most robust and efficient excipients, it tolerates high salt content, high temperature and is stable in a wide pH range. Low use levels of GRINDSTED® Xanthan Gum are sufficient to provide desired viscosities and textures. At the same time, its pronounced shear-thinning behavior enables handling of even highly viscous solutions.

Contact us for further information.

Well-recognized product that can do it all

METHOCEL™ cellulose ethers are water-soluble polymers derived from cellulose.

The product range encompasses methylcellulose and hydroxypropyl methylcellulose (hypromellose) – each available in different grades to address a wide range of applications including tablet coatings, granulation, controlled release, drug layering, vegetarian hard-shell capsules and amorphous drug stabilization.

METHOCEL™ products have been in continuous production for more than 70 years with production facilities and deep product expertise located around the globe.

The METHOCEL™ Premium family of water-soluble polymers for pharmaceutical applications offers exceptional flexibility and a broad range of properties typically not found in other water-soluble polymers. In many applications, one METHOCEL™ product can perform the job of two, three or even more ingredients saving money and time.

Contact us for further information.

Truly distinctive drug delivery solutions

POLYOX™ resins are nonionic polyethylene oxide solubility polymers. They are white to off-white, free-flowing hydrophilic powders supplied in a variety of viscosity grades corresponding to approximate molecular weight, ranging from 100,000 to 7,000,000 daltons.

Contact us for further information.

Efficacy in many dosage forms

TEXTURECEL™ is highly purified sodium carboxymethyl cellulose (NaCMC) that forms clear solutions in water at all temperatures, has exceptional water binding properties, and is available in a wide range of viscosity grades.

TEXTURECEL™ NaCMC is applied in oral solids, such as granules and pellets, powders as well as coatings for tablets. It is highly versatile and is therefore also widely used in topicals and semi-solid & liquid dosage forms, including ointments, creams, gels, pastes, solutions, suspensions, and emulsions. Our customers around the world enjoy the benefits of TEXTURECEL™ NaCMC in various wound care products, too.

Contact us for further information.